Structure of PDB 8iuh Chain P

Receptor sequence
>8iuhP (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
DPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQL
DLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIR
YKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTG
GAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPMIQRNSSFASS
HEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSV
DGHMKLYRAVNPIIPPTGLVRAPCGLCPVFDDCHEGGEISPSNCIYMTEW
LEF
3D structure
PDB8iuh Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
ChainP
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna P L120 K140 K147 K148 L107 K127 K134 K135
BS02 SF4 P C287 C290 F293 C296 P304 C307 M310 C274 C277 F280 C283 P291 C294 M297
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006359 regulation of transcription by RNA polymerase III
GO:0006383 transcription by RNA polymerase III
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iuh, PDBe:8iuh, PDBj:8iuh
PDBsum8iuh
PubMed37165065
UniProtQ9H1D9|RPC6_HUMAN DNA-directed RNA polymerase III subunit RPC6 (Gene Name=POLR3F)

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