Structure of PDB 7znk Chain P

Receptor sequence
>7znkP (length=367) Species: 9606 (Homo sapiens) [Search protein sequence]
LKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAMGKTAVFVLATL
QQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSI
KKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQ
LDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVKLT
LHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLV
EQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNI
AFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFE
VNISELPDEIDISSYIE
3D structure
PDB7znk mRNA recognition and packaging by the human transcription-export complex.
ChainP
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna P T122 R123 G150 G151 T172 P173 G174 R175 D206 T68 R69 G96 G97 T118 P119 G120 R121 D152
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008186 ATP-dependent activity, acting on RNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017070 U6 snRNA binding
GO:0030621 U4 snRNA binding
GO:0042802 identical protein binding
GO:0043008 ATP-dependent protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010501 RNA secondary structure unwinding
GO:0051028 mRNA transport
Cellular Component
GO:0000346 transcription export complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005687 U4 snRNP
GO:0005688 U6 snRNP
GO:0005737 cytoplasm
GO:0016607 nuclear speck

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7znk, PDBe:7znk, PDBj:7znk
PDBsum7znk
PubMed37020021
UniProtQ13838|DX39B_HUMAN Spliceosome RNA helicase DDX39B (Gene Name=DDX39B)

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