Structure of PDB 7xd8 Chain P

Receptor sequence

>7xd8P (length=611) Species: 11060 (dengue virus type 2)

ETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASS
MVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPKEG
TKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKW
KSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAK
GSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGYIL
RDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIF
KLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQL
IRQMEGEGVFEEIAVKNWLVRVGRERLSRMAISGDDCVVKPLDDRFASAL
TALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPC
RNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANA
ICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWMEDKT
PVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEE
YTDYMPSMKRF

3D structure

• PDB: 7xd8 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
• Chain: P
• Resolution: 2.85 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	P	A408 I474 Y476 R482 N493 H513 G602 Q603 V604 W803 M804 V812	A139 I205 Y207 R213 N224 H244 G333 Q334 V335 W525 M526 V534
BS02	rna	P	S405 Y607 S661 G662 D663 C709 S710 L754 S757 Y758 M761 T790 S791 R792	S136 Y338 S383 G384 D385 C431 S432 L476 S479 Y480 M483 T512 S513 R514
BS03	ZN	P	H712 H714 C728 C847	H434 H436 C450 C569
BS04	ZN	P	E438 H442 C447 C450	E169 H173 C178 C181

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005524 ATP binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7xd8, PDBe:7xd8, PDBj:7xd8
• PDBsum: 7xd8
• PubMed: 36577062
• UniProt: Q91H74