Structure of PDB 7x0s Chain P

Receptor sequence
>7x0sP (length=527) Species: 9606 (Homo sapiens) [Search protein sequence]
HVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMN
KMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNF
VLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKN
LRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDNIR
VCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITET
KGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALH
YANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLS
EVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLT
RDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALA
ENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGILDTYLG
KYWAIKLATNAAVTVLRVDQIIMAKPA
3D structure
PDB7x0s Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.
ChainP
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP P Y47 G48 P49 D99 G100 T101 N102 F103 M169 G412 L452 I497 Y44 G45 P46 D96 G97 T98 N99 F100 M166 G409 L449 I494
BS02 MG P D99 S170 D96 S167
BS03 AF3 P D68 D99 T101 K171 D65 D96 T98 K168
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0044183 protein folding chaperone
GO:0045296 cadherin binding
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0061077 chaperone-mediated protein folding
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0002199 zona pellucida receptor complex
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005929 cilium
GO:0034774 secretory granule lumen
GO:0035578 azurophil granule lumen
GO:0044297 cell body
GO:0045111 intermediate filament cytoskeleton
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x0s, PDBe:7x0s, PDBj:7x0s
PDBsum7x0s
PubMed37193829
UniProtP50990|TCPQ_HUMAN T-complex protein 1 subunit theta (Gene Name=CCT8)

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