Structure of PDB 7s81 Chain P

Receptor sequence
>7s81P (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
AVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKEN
RYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNF
TKYPKKFYPLEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQI
LDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAY
3D structure
PDB7s81 Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
ChainP
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna P W589 K600 W58 K69
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7s81, PDBe:7s81, PDBj:7s81
PDBsum7s81
PubMed35793673
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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