Structure of PDB 7r50 Chain P

Receptor sequence
>7r50P (length=465) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVA
NMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPV
TLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCAGVDRFARVR
DIALSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAI
RAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGH
QAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGA
MCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAA
GASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVFDRARKGL
FEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVV
LGVQSAAGFAEGHPL
3D structure
PDB7r50 The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain.
ChainP
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.7.1.7: GMP reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP P M53 G300 A301 C303 D336 G337 G338 M357 G359 S360 G386 A388 R391 E413 M52 G299 A300 C302 D335 G336 G337 M356 G358 S359 G385 A387 R390 E403
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003920 GMP reductase activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006166 purine ribonucleoside salvage
GO:0032264 IMP salvage
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r50, PDBe:7r50, PDBj:7r50
PDBsum7r50
PubMed35338694
UniProtA0QYE8|GUAB1_MYCS2 GMP reductase (Gene Name=guaB1)

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