Structure of PDB 7r44 Chain P

Receptor sequence
>7r44P (length=341) Species: 9913 (Bos taurus) [Search protein sequence]
LHHAVIPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIVPHR
CEPYDTMHLRPMGDLGQIIFMDWNGRDKDSIRRAVEHSSVVINLVGREWE
TQNFDFEDVFVKIPQAIAQVSKEAGVEKFIHISHLNADIKSSSKYLRSKA
VGEKEVRETFPEATIIKPAEIFGREDRFLNYFANIRWFGGVPLISLGKKT
VKQPVYIVDVTKGIINAIKDPDARGKTFAFVGPSRYLLFDLVQYVFAVAH
RPFLPYPLPHFAYRWIGRLFEISPFEPWTTRDKVERIHTTDKILPHLPGL
EDLGVEATPLELKAIEVLRRHRTYRWLSSEIEDVQPAKTIP
3D structure
PDB7r44 Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
ChainP
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP P G25 T27 G28 F29 L30 R50 W73 L94 V95 G96 R97 F104 I132 H134 Y145 K149 I171 R177 G25 T27 G28 F29 L30 R50 W73 L94 V95 G96 R97 F104 I132 H134 Y145 K149 I171 R177
Gene Ontology
Molecular Function
GO:0044877 protein-containing complex binding
Biological Process
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:1901006 ubiquinone-6 biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0045271 respiratory chain complex I

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Molecular Function
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Cellular Component
External links
PDB RCSB:7r44, PDBe:7r44, PDBj:7r44
PDBsum7r44
PubMed36701435
UniProtP34943|NDUA9_BOVIN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Gene Name=NDUFA9)

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