Structure of PDB 6x0m Chain P

Receptor sequence
>6x0mP (length=470) Species: 9606 (Homo sapiens) [Search protein sequence]
GKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLED
DAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWE
DREKFEKVPGKYDMLQMDSQLDLRVQELIKLICNVQAMEEMMMEMKYNTK
KAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDF
GLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYR
NLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEK
EAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYF
ADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKH
STKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYN
PNQVRMRYLLKVQFNFLQLW
3D structure
PDB6x0m Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.
ChainP
Resolution6.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S457 Y460 E545
Catalytic site (residue number reindexed from 1) S357 Y360 E445
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna P N114 N116 G139 R140 N38 N40 G63 R64
BS02 dna P Y119 W138 K170 Y188 Y43 W62 K94 Y112
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0031491 nucleosome binding
GO:0072572 poly-ADP-D-ribose binding
GO:0140294 NAD DNA ADP-ribosyltransferase activity
GO:0140805 NAD+-protein-serine ADP-ribosyltransferase activity
GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity
GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity
GO:0160004 poly-ADP-D-ribose modification-dependent protein binding
GO:1990404 NAD+-protein ADP-ribosyltransferase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006974 DNA damage response
GO:0030592 DNA ADP-ribosylation
GO:0046697 decidualization
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0070212 protein poly-ADP-ribosylation
GO:0070213 protein auto-ADP-ribosylation
GO:0090649 response to oxygen-glucose deprivation
GO:0097191 extrinsic apoptotic signaling pathway
GO:0110088 hippocampal neuron apoptotic process
GO:0140861 DNA repair-dependent chromatin remodeling
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6x0m, PDBe:6x0m, PDBj:6x0m
PDBsum6x0m
PubMed32939087
UniProtQ9UGN5|PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (Gene Name=PARP2)

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