Structure of PDB 6txe Chain P

Receptor sequence

>6txeP (length=474) Species: 9606 (Homo sapiens) [Search protein sequence]

TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDC
HHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLH
RRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYT
KLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKR
EDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSF
YCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFV
QWCADRNFTKPQDGDVIAPLITPQ

3D structure

PDB

6txe Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

3.19 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DTP	P	R333 R352 K354 N358 K523	R213 R232 K234 N238 K403
BS02	DTP	P	V156 F157 R372 H376 K377	V43 F44 R252 H256 K257
BS03	DTP	P	V117 N119	V4 N6
BS04	GTP	P	Y155 V156 R451	Y42 V43 R331
BS05	FE	P	H167 H206 D207 D311	H54 H93 D94 D191
BS06	1FZ	P	Q149 R164 D207 H215 H233 D311 K312 Y315 D319 Y374	Q36 R51 D94 H102 H120 D191 K192 Y195 D199 Y254
BS07	GTP	P	K116 V117 I118 D137 R145 F165	K3 V4 I5 D24 R32 F52

External links

PDB	RCSB:6txe, PDBe:6txe, PDBj:6txe
PDBsum	6txe
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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