Structure of PDB 6tm5 Chain P

Receptor sequence
>6tm5P (length=492) Species: 9606 (Homo sapiens) [Search protein sequence]
FSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLAELQPPPP
ITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLS
GEKKKDDETVKNEALRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVK
EAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAH
IYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIF
NELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCV
IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQ
AYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRML
VALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQA
AQCYIKYIQDIYSCTAFRYLAQYYFKCKLWDEASTCAQKCCA
3D structure
PDB6tm5 A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
ChainP
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide P R277 Y308 V309 H373 Y399 R400 R241 Y272 V273 H337 Y363 R364
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007080 mitotic metaphase chromosome alignment
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007096 regulation of exit from mitosis
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tm5, PDBe:6tm5, PDBj:6tm5
PDBsum6tm5
PubMed32307883
UniProtQ9UJX2|CDC23_HUMAN Cell division cycle protein 23 homolog (Gene Name=CDC23)

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