Structure of PDB 6ow2 Chain P

Receptor sequence
>6ow2P (length=191) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
SAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQ
FLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNAYDLEAIMYN
PKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHRI
KLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLIL
3D structure
PDB6ow2 Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections.
ChainP
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) G72 Q77 C130 L131 H173 E174 H177
Catalytic site (residue number reindexed from 1) G71 Q76 C119 L120 H162 E163 H166
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NB4 P Q57 G69 G70 V71 G72 Q77 E128 C130 L131 V170 H173 E174 H177 Q56 G68 G69 V70 G71 Q76 E117 C119 L120 V159 H162 E163 H166 MOAD: ic50=3nM
PDBbind-CN: -logKd/Ki=8.52,IC50=3nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0043686 co-translational protein modification

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ow2, PDBe:6ow2, PDBj:6ow2
PDBsum6ow2
PubMed31160176
UniProtQ8DP79|DEF_STRR6 Peptide deformylase (Gene Name=def)

[Back to BioLiP]