Structure of PDB 5w5o Chain P

Receptor sequence
>5w5oP (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDV
LREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEY
PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIA
DFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNP
LQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLK
CLIELEPVLRTFEEITFLEAVIQLK
3D structure
PDB5w5o Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.
ChainP
Resolution2.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 K148 Q150 N151 D164 T189
Catalytic site (residue number reindexed from 1) D133 K135 Q137 N138 D151 T161
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9XA P S25 A45 L79 T95 M98 G101 S102 L153 A163 S21 A41 L66 T82 M85 G88 S89 L140 A150 BindingDB: IC50=8.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5w5o, PDBe:5w5o, PDBj:5w5o
PDBsum5w5o
PubMed29057049
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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