Structure of PDB 5umd Chain P

Receptor sequence

>5umdP (length=204) Species: 36329 (Plasmodium falciparum 3D7)

GAYKYIQEIWKKKQSDAMHFLLRVRTWEYRQLPVVHRVSKPSRPDKARRL
GYKAIQGFVIYRVRVRRGDRKKRVKKGIVHGKPKHQGVHKQKSTRNLKSV
AEGKVGKSICGNLRVLNSYWVGQDAVYKYYEVILVDPNHNAVRNNPKINW
ICNPVHKHRELRGLTSAGKKYRGLRVKGHLSAKSRPSIRANWKRRQLIKL
RKCR

3D structure

• PDB: 5umd Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
• Chain: P
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	P	G2 Y4 K5 K12 K14 Q15 R24 W28 R31 P34 V35 K41 R44 K47 R49 R50 L51 K54 A55 Q57 R67 R68 G69 D70 R71 K72 K73 R74 V75 K77 G78 I79 H81 G82 K83 P84 K85 H86 Q87 V89 K91 K93 S94 T95 R96 N97 L98 K108 N113 W121 D125 A126 Y128 N139 N141 N145 N146 K148 W151 P155 V156 H157 K158 H159 R160 L162 R163 S167 K171 Y172 R173 L175 R176 K178 H180 L181 A183 K184 R186 P187 S188 R190 A191 W193 K194 R195 R196 K200 R202 K203 R205	G1 Y3 K4 K11 K13 Q14 R23 W27 R30 P33 V34 K40 R43 K46 R48 R49 L50 K53 A54 Q56 R66 R67 G68 D69 R70 K71 K72 R73 V74 K76 G77 I78 H80 G81 K82 P83 K84 H85 Q86 V88 K90 K92 S93 T94 R95 N96 L97 K107 N112 W120 D124 A125 Y127 N138 N140 N144 N145 K147 W150 P154 V155 H156 K157 H158 R159 L161 R162 S166 K170 Y171 R172 L174 R175 K177 H179 L180 A182 K183 R185 P186 S187 R189 A190 W192 K193 R194 R195 K199 R201 K202 R204
BS02	rna	P	R38 Q57 V60 Y62 I110 N113 D137 H140	R37 Q56 V59 Y61 I109 N112 D136 H139

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5umd, PDBe:5umd, PDBj:5umd
• PDBsum: 5umd
• PubMed: 28288098
• UniProt: C0H4A6