Structure of PDB 5lsp Chain P

Receptor sequence
>5lspP (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
GCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKV
FPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSEST
MNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGP
MAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTIST
EFAVKLKIDLANRETSIFSYRE
3D structure
PDB5lsp Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.
ChainP
Resolution2.605 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide P Y566 F569 T582 C584 T618 N620 T621 Y48 F51 T64 C66 T100 N102 T103
Gene Ontology
Molecular Function
GO:0017154 semaphorin receptor activity
Biological Process
GO:0071526 semaphorin-plexin signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5lsp, PDBe:5lsp, PDBj:5lsp
PDBsum5lsp
PubMed28827556
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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