Structure of PDB 5iy9 Chain P

Receptor sequence
>5iy9P (length=185) Species: 9606 (Homo sapiens) [Search protein sequence]
TPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIM
RIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLD
FKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVL
LIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRK
3D structure
PDB5iy9 Near-atomic resolution visualization of human transcription promoter opening.
ChainP
Resolution6.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna P T171 F214 K218 Q256 N257 F288 R294 T313 T19 F62 K66 Q104 N105 F136 R142 T161
BS02 dna P N167 F197 R203 T210 T222 P289 F305 K309 V311 N15 F45 R51 T58 T70 P137 F153 K157 V159
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0001046 core promoter sequence-specific DNA binding
GO:0001091 RNA polymerase II general transcription initiation factor binding
GO:0001093 TFIIB-class transcription factor binding
GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0017162 aryl hydrocarbon receptor binding
GO:0019899 enzyme binding
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
GO:0140297 DNA-binding transcription factor binding
Biological Process
GO:0001188 RNA polymerase I preinitiation complex assembly
GO:0006352 DNA-templated transcription initiation
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0006383 transcription by RNA polymerase III
GO:0007283 spermatogenesis
GO:0042789 mRNA transcription by RNA polymerase II
GO:0045893 positive regulation of DNA-templated transcription
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0001673 male germ cell nucleus
GO:0001674 female germ cell nucleus
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005668 RNA polymerase transcription factor SL1 complex
GO:0005669 transcription factor TFIID complex
GO:0005672 transcription factor TFIIA complex
GO:0005737 cytoplasm
GO:0032991 protein-containing complex
GO:0045120 pronucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:5iy9, PDBe:5iy9, PDBj:5iy9
PDBsum5iy9
PubMed27193682
UniProtP20226|TBP_HUMAN TATA-box-binding protein (Gene Name=TBP)

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