Structure of PDB 4eox Chain P

Receptor sequence
>4eoxP (length=192) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
SAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQ
FLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIAYDLEAIMY
NPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHR
IKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLIL
3D structure
PDB4eox Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
ChainP
Resolution1.783 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0S5 P G69 G70 V71 G72 Q77 G129 C130 L131 V170 H173 E174 H177 G68 G69 V70 G71 Q76 G119 C120 L121 V160 H163 E164 H167 MOAD: ic50=0.28nM
PDBbind-CN: -logKd/Ki=9.55,IC50=0.28nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0043686 co-translational protein modification

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Molecular Function
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Biological Process
External links
PDB RCSB:4eox, PDBe:4eox, PDBj:4eox
PDBsum4eox
PubMed22579486
UniProtQ8DP79|DEF_STRR6 Peptide deformylase (Gene Name=def)

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