Structure of PDB 4crn Chain P

Receptor sequence
>4crnP (length=430) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GGKDHVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAKDAGRQ
GWYLSWVMDTNKEERNDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEM
IGGASQADVGVLVISARKGEYETGFERGGQTREHALLAKTQGVNKMVVVV
NKMDDPTVNWSKERYDQCVSNVSNFLRAIGYNIKTDVVFMPVSGYSGANL
KDHVDPKECPWYTGPTLLEYLDTMNHVDRHINAPFMLPIAAKMKDLGTIV
EGKIESGHIKKGQSTLLMPNKTAVEIQNIYNETENEVDMAMCGEQVKLRI
KGVEEEDISPGFVLTSPKNPIKSVTKFVAQIAIVELKSIIAAGFSCVMHV
HTAIEEVHIVKLLHKLEKGTNRKSKKPPAFAKKGMKVIAVLETEAPVCVE
TYQDYPQLGRFTLRDQGTTIAIGKIVKIAE
3D structure
PDB4crn Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing Erf1-Erf3 or Erf1-Abce1.
ChainP
Resolution9.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K272 S273 T324 H347
Catalytic site (residue number reindexed from 1) K18 S19 T70 H93
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP P V268 D269 A270 G271 K272 S273 Q304 Y307 T324 I325 A344 P345 G346 K348 N405 K406 D409 V14 D15 A16 G17 K18 S19 Q50 Y53 T70 I71 A90 P91 G92 K94 N151 K152 D155
Gene Ontology
Molecular Function
GO:0003747 translation release factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006415 translational termination

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Molecular Function
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Biological Process
External links
PDB RCSB:4crn, PDBe:4crn, PDBj:4crn
PDBsum4crn
PubMed25001285
UniProtP05453|ERF3_YEAST Eukaryotic peptide chain release factor GTP-binding subunit (Gene Name=SUP35)

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