Structure of PDB 3sw8 Chain P

Receptor sequence
>3sw8P (length=194) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
SAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQ
FLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIEAYDLEAIM
YNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKH
RIKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE
3D structure
PDB3sw8 Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors.
ChainP
Resolution1.702 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5LI P G70 V71 G72 Q77 E128 G129 C130 L131 V170 H173 E174 H177 G69 V70 G71 Q76 E119 G120 C121 L122 V161 H164 E165 H168 MOAD: Ki=25910nM
PDBbind-CN: -logKd/Ki=4.50,Ki=31.72uM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0018206 peptidyl-methionine modification

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Molecular Function
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Biological Process
External links
PDB RCSB:3sw8, PDBe:3sw8, PDBj:3sw8
PDBsum3sw8
PubMed21711014
UniProtQ939R9

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