Structure of PDB 3svj Chain P

Receptor sequence
>3svjP (length=193) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
SAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQ
FLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIAYDLEAIMY
NPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHR
IKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE
3D structure
PDB3svj Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors.
ChainP
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4LI P G69 V71 E126 G127 E128 G129 H173 G68 V70 E116 G117 E118 G119 H163 MOAD: Ki=117nM
PDBbind-CN: -logKd/Ki=6.93,Ki=117nM
BindingDB: Ki=117nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0043686 co-translational protein modification

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3svj, PDBe:3svj, PDBj:3svj
PDBsum3svj
PubMed21711014
UniProtQ8DP79|DEF_STRR6 Peptide deformylase (Gene Name=def)

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