Structure of PDB 3lvf Chain P

Receptor sequence

>3lvfP (length=338) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252)

GSMAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYD
TMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTG
FYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSG
ASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRR
ARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVV
LEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTR
VMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK

3D structure

• PDB: 3lvf Crystal Structure of Glyceraldehyde-3-Phosphate Dehydrogenase 1 from Methicillin-Resistant Staphylococcus aureus MRSA252 Provides Novel Insights into Substrate Binding and Catalytic Mechanism.
• Chain: P
• Resolution: 1.7 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	P	G11 R12 I13 D34 L35 P78 T97 G98 F99 S120 C151 N316 Y320	G13 R14 I15 D36 L37 P80 T99 G100 F101 S122 C153 N318 Y322

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0030554 adenyl nucleotide binding
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3lvf, PDBe:3lvf, PDBj:3lvf
• PDBsum: 3lvf
• PubMed: 20620151
• UniProt: Q6GIL8|G3P1_STAAR Glyceraldehyde-3-phosphate dehydrogenase 1 (Gene Name=gapA1)