Structure of PDB 3ko0 Chain P

Receptor sequence
>3ko0P (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
ACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTD
EAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGF
3D structure
PDB3ko0 Phenothiazines inhibit S100A4 function by inducing protein oligomerization.
ChainP
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TFP P F89 F93 F88 F92
BS02 TFP P E6 D10 E5 D9
BS03 TFP P C86 F89 C85 F88
BS04 CA P S20 E23 D25 K28 E33 S19 E22 D24 K27 E32
BS05 CA P D63 N65 D67 E69 E74 D62 N64 D66 E68 E73
BS06 TFP P S44 F45 L46 G47 M85 C86 F93 S43 F44 L45 G46 M84 C85 F92
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0048306 calcium-dependent protein binding
GO:0050786 RAGE receptor binding
Biological Process
GO:0001837 epithelial to mesenchymal transition
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0050918 positive chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ko0, PDBe:3ko0, PDBj:3ko0
PDBsum3ko0
PubMed20421509
UniProtP26447|S10A4_HUMAN Protein S100-A4 (Gene Name=S100A4)

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