Structure of PDB 3hx0 Chain P

Receptor sequence

>3hx0P (length=327) Species: 9606 (Homo sapiens)

ATNHNLHITEKLEVLAKAYSVQGDKWRAAGYAKAINALKSFHKPVTSYQE
ACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKT
AQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQT
VQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLL
DSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSE
FACALLYFTGSAAFNASMRALAKTKGMSLSEHALSTAVVRNTHGAKVGPG
RVLPTPTEKDVFRLLGLPYREPAERDW

3D structure

• PDB: 3hx0 Scrunching During DNA Repair Synthesis
• Chain: P
• Resolution: 3.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D427 D429 D490
• Catalytic site (residue number reindexed from 1): D179 D181 D242
• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.
  4.2.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	P	W274 T371 Q464 E465 Y505 R517 K521	W26 T123 Q216 E217 Y257 R269 K273
BS02	dna	P	W342 G343 A344 G345 K347 T348	W94 G95 A96 G97 K99 T100
BS03	dna	P	Y267 W274 R275 G278 Y279 G304 G306 R308 M309 K312	Y19 W26 R27 G30 Y31 G56 G58 R60 M61 K64
BS04	D3T	P	R386 G416 S417 R420 G426 D427 D429 F506 A510	R138 G168 S169 R172 G178 D179 D181 F258 A262
BS05	MG	P	D427 D429	D179 D181

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0034061 DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:3hx0, PDBe:3hx0, PDBj:3hx0
• PDBsum: 3hx0
• UniProt: Q9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)