Structure of PDB 3hbu Chain P

Receptor sequence

>3hbuP (length=462) Species: 556 (Dickeya chrysanthemi) [Search protein sequence]

ANTSSAYNSVYDFLRYHDRGDGLTVNGKTSYSIDQAAAQITRENVSWNGT
NVFGKSANLTFKFLQSVSSIPSGDTGFVKFNAEQIEQAKLSLQSWSDVAN
LTFTEVTGNKSANITFGNYTRDASGNLDYGTQAYAYYPGNYQGAGSSWYN
YNQSNIRNPGSEEYGRQTFTHEIGHALGLAHPGEYNAGEGDPSYNDAVYA
EDSYQFSIHSYWGENETGADYNGHYGGAPMIDDIAAIQRLYGANMTTRTG
DSVYGFNSNTDRDFYTATDSSKALIFSVWDAGGTDTFDFSGYSNNQRINL
NEGSFSDVGGLKGNVSIAHGVTIENAIGGSGNDILVGNSADNILQGGAGN
DVLYGGAGADTLYGGAGRDTFVYGSGQDSTVAAYDWIADFQKGIDKIDLS
AFRNEGQLSFVQDQFTGKGQEVMLQWDAANSITNLWLHEAGHSSVDFLVR
IVGQAAQSDIIV

3D structure

PDB

3hbu Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site

Chain

Resolution

1.77 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.4.24.40: serralysin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	P	A150 Y151 A152 Y153 Y154 H192 N203 A204 Y228	A133 Y134 A135 Y136 Y137 H175 N186 A187 Y211
BS02	CA	P	R265 G267 S269 D297 G299 D302	R248 G250 S252 D280 G282 D285
BS03	CA	P	G300 D302 T339 E341	G283 D285 T322 E324
BS04	CA	P	G346 G348 D350 G363 G364 A365 D368	G329 G331 D333 G346 G347 A348 D351
BS05	CA	P	N355 A357 N359 G372 A374 D377	N338 A340 N342 G355 A357 D360
BS06	CA	P	G364 A365 G366 D368 G381 G382 A383 D386	G347 A348 G349 D351 G364 G365 A366 D369
BS07	CA	P	G382 G384 D386 Q408 D412	G365 G367 D369 Q391 D395
BS08	ZN	P	H188 H192 H198	H171 H175 H181
BS09	ZN	P	H188 H192 H198 H226	H171 H175 H181 H209
BS10	ZN	P	E180 H241	E163 H224
BS11	CA	P	G373 A374 G375 D377 D395 D402	G356 A357 G358 D360 D378 D385

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031012	extracellular matrix

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3hbu, PDBe:3hbu, PDBj:3hbu
PDBsum	3hbu
PubMed	19558324
UniProt	P16317\|PRTC_DICCH Serralysin C (Gene Name=prtC)

[Back to BioLiP]