Structure of PDB 2pbd Chain P

Receptor sequence
>2pbdP (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
AGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVL
VGKDRSSFYVNGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNV
TVTKTDKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
3D structure
PDB2pbd Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP
ChainP
Resolution1.501 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide P W3 Y6 S27 W31 H133 Y139 W3 Y6 S27 W31 H133 Y139
Gene Ontology
Molecular Function
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0001784 phosphotyrosine residue binding
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0031267 small GTPase binding
GO:0045296 cadherin binding
GO:0070064 proline-rich region binding
Biological Process
GO:0001843 neural tube closure
GO:0006357 regulation of transcription by RNA polymerase II
GO:0010634 positive regulation of epithelial cell migration
GO:0030036 actin cytoskeleton organization
GO:0030833 regulation of actin filament polymerization
GO:0030837 negative regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0032232 negative regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032781 positive regulation of ATP-dependent activity
GO:0044087 regulation of cellular component biogenesis
GO:0050804 modulation of chemical synaptic transmission
GO:0050821 protein stabilization
GO:0051497 negative regulation of stress fiber assembly
GO:0060074 synapse maturation
GO:0098885 modification of postsynaptic actin cytoskeleton
GO:0110053 regulation of actin filament organization
GO:1900029 positive regulation of ruffle assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0098978 glutamatergic synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2pbd, PDBe:2pbd, PDBj:2pbd
PDBsum2pbd
PubMed17914456
UniProtP07737|PROF1_HUMAN Profilin-1 (Gene Name=PFN1)

[Back to BioLiP]