Structure of PDB 2c39 Chain P

Receptor sequence
>2c39P (length=248) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence]
MREMLQVERPKLILDDGKRTDGRKPDELRSIKIELGVLKNADGSAIFEMG
NTKAIAAVYGPKEMHPRHLSLPDRAVLRVRYHMTPFSTDERKNPAPSRRE
IELSKVIREALESAVLVELFPRTAIDVFTEILQADAGSRLVSLMAASLAL
ADAGIPMRDLIAGVAVGKADGVIILDLNETEDMWGEADMPIAMMPSLNQV
TLFQLNGSMTPDEFRQAFDLAVKGINIIYNLEREALKSKYVEFKEEGV
3D structure
PDB2c39 Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core.
ChainP
Resolution3.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP P T88 R99 A134 A136 G137 S138 R139 E179 D182 T88 R99 A134 A136 G137 S138 R139 E179 D182
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003723 RNA binding
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters
Biological Process
GO:0006401 RNA catabolic process
GO:0016075 rRNA catabolic process
Cellular Component
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2c39, PDBe:2c39, PDBj:2c39
PDBsum2c39
PubMed16285928
UniProtQ9UXC2|RRP41_SACS2 Exosome complex component Rrp41 (Gene Name=rrp41)

[Back to BioLiP]