Structure of PDB 2aig Chain P

Receptor sequence
>2aigP (length=201) Species: 8729 (Crotalus adamanteus) [Search protein sequence]
NLPQRYIELVVVADRRVFMKYNSDLNIIRTRVHEIVNIINEFYRSLNIRV
SLTDLEIWSGQDFITIQSSSSNTLNSFGEWRERVLLTRKRHDNAQLLTAI
NFEGKIIGKAYTSSMCNPRSSVGIVKDHSPINLLVAVTMAHELGHNLGME
HDGKDCLRGASLCIMRPGLTPGRSYEFSDDSMGYYQKFLNQYKPQCILNK
P
3D structure
PDB2aig Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors.
ChainP
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.46: adamalysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0GR P G105 K106 I107 I108 T139 H142 E143 I165 R167 P168 G169 L170 G104 K105 I106 I107 T138 H141 E142 I164 R166 P167 G168 L169 PDBbind-CN: -logKd/Ki=5.00,IC50=10uM
BS02 ZN P H142 H146 H152 H141 H145 H151
BS03 CA P E9 D93 C197 N200 E8 D92 C196 N199
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:2aig, PDBe:2aig, PDBj:2aig
PDBsum2aig
PubMed9521103
UniProtP34179|VM12_CROAD Snake venom metalloproteinase adamalysin-2

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