Structure of PDB 2aie Chain P

Receptor sequence
>2aieP (length=194) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
SAIERIVKAAHLIDMCDIIREGNPSLRTVAEEVTFPLSDQEIILGEKMMQ
FLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIEAYDLEAIM
YNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKH
RIKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE
3D structure
PDB2aie Structural Variation and inhibitor binding in polypeptide deformylase from four different bacterial species
ChainP
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SB9 P G71 Q76 L123 E128 C130 L131 Y166 H173 E174 H177 G71 Q76 L115 E119 C121 L122 Y157 H164 E165 H168 MOAD: ic50=2.2uM
PDBbind-CN: -logKd/Ki=5.66,IC50=2.2uM
BindingDB: IC50=2200nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0043686 co-translational protein modification

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Molecular Function
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Biological Process
External links
PDB RCSB:2aie, PDBe:2aie, PDBj:2aie
PDBsum2aie
PubMed12538898
UniProtQ8DP79|DEF_STRR6 Peptide deformylase (Gene Name=def)

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