Structure of PDB 1i1i Chain P

Receptor sequence
>1i1iP (length=665) Species: 10116 (Rattus norvegicus) [Search protein sequence]
MSSYTAAGRNVLRWDLSPEQIKTRTEQLIAQTKQVYDTVGTIALKEVTYE
NCLQVLADIEVTYIVERTMLDFPQHVSSDREVRAASTEADKKLSRFDIEM
SMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHLSEHIRN
EIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDE
DKYKVTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKQENTAILQQLLPL
RAQVAKLLGYNTHADFVLELNTAKSTSRVAAFLDDLSQKLKPLGEAEREF
ILSLKKKECEERGFEYDGKINAWDLHYYMTQTEELKYSVDQESLKEYFPI
EVVTEGLLSIYQELLGLSFEQVPDAHVWNKSVSLYTVKDKATGEVLGQFY
LDLYPREGKYNHAACFGLQPGCLLPDGSRMMSVAALVVNFSQPVAGRPSL
LRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWV
WDVDSLRKLSKHYKDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQ
SLHTNATLDAASEYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGY
LWSEVFSMDMFHSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLQNFL
QREPNQKAFLMSRGL
3D structure
PDB1i1i Structure of neurolysin reveals a deep channel that limits substrate access.
ChainP
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H474 E475 H478 E503 Y613
Catalytic site (residue number reindexed from 1) H461 E462 H465 E490 Y600
Enzyme Commision number 3.4.24.16: neurolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN P H474 H478 E503 H461 H465 E490
BS02 ZN P H160 E164 H147 E151
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070012 oligopeptidase activity
Biological Process
GO:0006111 regulation of gluconeogenesis
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0030163 protein catabolic process
GO:0043171 peptide catabolic process
GO:1902809 regulation of skeletal muscle fiber differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1i1i, PDBe:1i1i, PDBj:1i1i
PDBsum1i1i
PubMed11248043
UniProtP42676|NEUL_RAT Neurolysin, mitochondrial (Gene Name=Nln)

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