Structure of PDB 1eed Chain P

Receptor sequence
>1eedP (length=330) Species: 5116 (Cryphonectria parasitica) [Search protein sequence]
STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTA
SEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLT
VTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKA
SLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTST
GYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGG
YVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGI
GINIFGDVALKAAFVVFNGATTPTLGFASK
3D structure
PDB1eed X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors.
ChainP
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.22: endothiapepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0EO P I7 D30 D32 G34 S74 Y75 G76 D77 D215 G217 T218 T219 I10 D33 D35 G37 S78 Y79 G80 D81 D219 G221 T222 T223 MOAD: Ki=16.2uM
PDBbind-CN: -logKd/Ki=4.79,Ki=16.2uM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1eed, PDBe:1eed, PDBj:1eed
PDBsum1eed
PubMed1525155
UniProtP11838|CARP_CRYPA Endothiapepsin (Gene Name=EAPA)

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