Structure of PDB 1e33 Chain P

Receptor sequence
>1e33P (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]
RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSL
CTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLT
GMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPC
DGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQREDRP
FFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDL
GLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFW
PGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKS
PRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASS
SLTAHEPLLLYDLSKDPGENYNLLGATPEVLQALKQLQLLKAQLDAAVTF
GPSQVARGEDPALQICCHPGCTPRPACCHCP
3D structure
PDB1e33 Defective oligomerization of arylsulfatase a as a cause of its instability in lysosomes and metachromatic leukodystrophy.
ChainP
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D29 D30 C69 H229 D281 N282 K302
Catalytic site (residue number reindexed from 1) D11 D12 C51 H211 D263 N264 K284
Enzyme Commision number 3.1.6.8: cerebroside-sulfatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG P D29 D30 X69 D281 N282 D11 D12 X51 D263 N264
Gene Ontology
Molecular Function
GO:0004065 arylsulfatase activity
GO:0004098 cerebroside-sulfatase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008484 sulfuric ester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006629 lipid metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0035578 azurophil granule lumen
GO:0043202 lysosomal lumen
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1e33, PDBe:1e33, PDBj:1e33
PDBsum1e33
PubMed11777924
UniProtP15289|ARSA_HUMAN Arylsulfatase A (Gene Name=ARSA)

[Back to BioLiP]