Structure of PDB 1bru Chain P

Receptor sequence
>1bruP (length=241) Species: 9823 (Sus scrofa) [Search protein sequence]
VVGGEDARPNSWPWQVSLQYDSSGQWRHTCGGTLVDQSWVLTAAHCISSS
RTYRVVLGRHSLSTNEPGSLAVKVSKLVVHQDWNSNQLSNGNDIALLKLA
SPVSLTDKIQLGCLPAAGTILPNNYVCYVTGWGRLQTNGASPDILQQGQL
LVVDYATCSKPGWWGSTVKTNMICAGGDGIISSCNGDSGGPLNCQGANGQ
WQVHGIVSFGSSLGCNYYHKPSVFTRVSNYIDWINSVIANN
3D structure
PDB1bru ?
ChainP
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G193 S195 G196
Catalytic site (residue number reindexed from 1) G186 S188 G189
Enzyme Commision number 3.4.21.71: pancreatic elastase II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1NB P H57 C191 N192 G193 D194 S195 H45 C184 N185 G186 D187 S188
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0032868 response to insulin
GO:0050796 regulation of insulin secretion
GO:0090330 regulation of platelet aggregation
GO:1901143 insulin catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Cellular Component
External links
PDB RCSB:1bru, PDBe:1bru, PDBj:1bru
PDBsum1bru
PubMed
UniProtP08419|CEL2A_PIG Chymotrypsin-like elastase family member 2A (Gene Name=CELA2A)

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