Structure of PDB 5juo Chain OA

Receptor sequence

>5juoOA (length=87) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

GKGTPSFGKRHNKSHTLCNRCGRRSFHVQKKTCSSCGYPAAKTRSYNWGA
KAKRRHTTGTGRMRYLKHVSRRFKNGFQTGSASKASA

3D structure

PDB

5juo Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.

Chain

Resolution

4.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	OA	G2 K3 G4 T5 P6 F8 G9 K10 H12 N13 S15 H16 R24 R25 S26 H28 Q30 K31 S35 S36 K43 R45 Y47 N48 W49 K52 A53 R55 R56 T58 S71 K75	G1 K2 G3 T4 P5 F7 G8 K9 H11 N12 S14 H15 R23 R24 S25 H27 Q29 K30 S34 S35 K42 R44 Y46 N47 W48 K51 A52 R54 R55 T57 S70 K74
BS02	rna	OA	K14 N20 R21 C22 F27 V29 K32 Y39 A42 H57 T58 T59 T61 G62 R63 M64 R65 Y66 L67 R72 F74 N76 F78 Q79 G81 S82 A83	K13 N19 R20 C21 F26 V28 K31 Y38 A41 H56 T57 T58 T60 G61 R62 M63 R64 Y65 L66 R71 F73 N75 F77 Q78 G80 S81 A82

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008270	zinc ion binding
GO:0019843	rRNA binding
GO:0046872	metal ion binding

	Biological Process
GO:0000448	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0030687	preribosome, large subunit precursor
GO:0044391	ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:5juo, PDBe:5juo, PDBj:5juo
PDBsum	5juo
PubMed	27159452
UniProt	P49166\|RL37A_YEAST Large ribosomal subunit protein eL37A (Gene Name=RPL37A)