Structure of PDB 6xza Chain O2

Receptor sequence

>6xzaO2 (length=117) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVA
ASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYH
GRVQALADAAREAGLQF

3D structure

PDB

6xza Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome.

Chain

Resolution

2.66 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	O2	R9 R10 T12 R13 R16 R94 Q98 Y99 F117	R9 R10 T12 R13 R16 R94 Q98 Y99 F117
BS02	rna	O2	K3 R15 R25 H29 R30 T31 P32 R33 H34 Y36 Q38 G44 S45 E46 V47 V54 E55 K56 K63 Y64 N67 K68 H100 G101 R102	K3 R15 R25 H29 R30 T31 P32 R33 H34 Y36 Q38 G44 S45 E46 V47 V54 E55 K56 K63 Y64 N67 K68 H100 G101 R102

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6xza, PDBe:6xza, PDBj:6xza
PDBsum	6xza
PubMed	32144191
UniProt	P0C018\|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)

[Back to BioLiP]