Structure of PDB 5vyc Chain O2

Receptor sequence

>5vycO2 (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]

EQVISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMK
VKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPG
AQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL

3D structure

PDB

5vyc Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.

Chain

Resolution

6.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	O2	D39 F41 H43 G49 K50 E51 T52 R55 T57 M60 D65 R66 E68 P134 I135 P136 S137 D138 S139 T140 R141 K143 G144 R146 R147 R149 R150 L151	D28 F30 H32 G38 K39 E40 T41 R44 T46 M49 D54 R55 E57 P123 I124 P125 S126 D127 S128 T129 R130 K132 G133 R135 R136 R138 R139 L140

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0045182	translation regulator activity
GO:0048027	mRNA 5'-UTR binding

	Biological Process
GO:0000028	ribosomal small subunit assembly
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0006417	regulation of translation
GO:0030218	erythrocyte differentiation
GO:0030490	maturation of SSU-rRNA
GO:0042274	ribosomal small subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:5vyc, PDBe:5vyc, PDBj:5vyc
PDBsum	5vyc
PubMed	28723557
UniProt	P62263\|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)