Structure of PDB 8tj5 Chain O

Receptor sequence

>8tj5O (length=1659) Species: 4932 (Saccharomyces cerevisiae)

MKWSAIPFQTLYRSIESGEFDFDLFKEVLPDLQNLNLNTDKLKNNASRSQ
LEKGEIELSDGSTFKVNQEFIFEAISLSDELNLDEIVACELILSGDTTAN
NGKVQYFLRRQYILQIVSFIVNCFHEDTELYQELIKNGALVSNILSAFKF
IHTQLSEIKQQINKAQILENYNALFQQNIKFRRDFLLREYDILSQILYGL
VDKGAIMKNKDFILSLLHHVSELDSNDFFIIYYTPAFFHLFASLRVLPDA
DVKLLHSQFMKDLKDDSIYTKPVKVALIFIFFAYFIGWCKEDPKRRADTM
DFKTDVDEPMTSAVELGAIEQILIFAADTSIVEQDKSMELFYDIRSLLER
HIPRLIPKQLLDDEKIFSQTTNSTYNPASATDNMSGNNVNEYSYTTIVLS
DQTQEFFLSSFDDVLQTIITDCAFLLTKIKDAEEDSLLSGEDLTLDDISL
KADLERFFLSIYFFYASRPEYSCTFWSDKESNAYGFIEWCSRCNDNLMRS
CFYLMVSSLSFGPENALNVYHYFGENSSISWKNIAQCLSDYTKKISNFNS
SLHKRQQFSESTHNDIDSTAVALEEGLNEEAVIFLSSLLTLVGSVTYQVD
EDVKSSLSKVFSDVLFEFTKINTPLVGAAFKVISNLVPKLESSRTKFWSF
LDSLIFKDSSLNYSSESYRNAFTNVLTKYSDVLGFLQLFHNLISIHSREN
NSEYMVFGKLAFPTRLGQGYRKVGIWPYFDYIFNDILAHVDQIVDIRNKR
AVQLPILKIIYTGLCSFDYSVILNSIPAAANLDALVDCENFFNYVQECPA
IPIFNYIFTEKIYKSIFNVVDVGVDQLSIELEGGKNQAELLQLAVKIINK
VLDYQETYVEELFPIVKKHGKTDYFLPKNYSLHGLRSFYDAIFFNIPLVA
HLGLYVGVDDQILATNSLRILAKLSERSNGSVASLSKRNKLLTIFDSVDE
SARIKDAFITQLESSITDAGVLALKLELLDFLTSNLSNYSRTMTISHLLL
GFQVSNVISLGPNLATFISSGTSLLDSLISVLEASLNSITKDNIDYAPMR
LATAALEIILKLCRNPLTSGLLYSYLIKENFFERIMILDPQVTRFTTWNG
SPFDNSTEEKCKNFIESESVGAFLSFLAYRNYWTQYLGLFIHKISFSGTK
SEVLTYVNYLISNTMYSVRLFSFLDPLNYGNICEPKETLSIFTNVPLNLE
QVTLNKYCSGNIYDFHKMENLMRLIKRVRAESLHSNSFSLTVSKEQFLKD
ADVECIKAKSHFTNIISRNKALELNLSVLHSWVQLVQIIVTDGKLEPSTR
SNFILEVFGTIIPKISDYIEFNITFSEELVSLAVFLFDIYNRDRKLITDK
GTVDGRLYQLFKTCIQGINSPLSSVALRSDFYILANHYLSRVLSDQVGSE
KVLQDLRLGSKKLVEIIWNDVVYGEGTSRVTGILLLDSLIQLANRSKENF
ILDSLMKTTRLLLIIRSLKNTDALLNSTTEHINIDDLLYELTAFKATVFF
LIRVAETRGGASALIENNLFRIIAELSFLKVDPDLGLDLMFDEVYVQNSK
FLKVNVTLDNPLLVDKDANGVSLFELIVPIFQLISAVLVSMGSSNKAVVQ
TVKGLLNTYKRLVIGIFKRDLLREKEDKKNSSDPNNQSLNEMVKLIVMLC
TLTGYQNND

3D structure

• PDB: 8tj5 Implications of a multiscale structure of the yeast nuclear pore complex.
• Chain: O
• Resolution: 6.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	O	I800 A804 N805 E884 E885	I776 A780 N781 E860 E861

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0017056 structural constituent of nuclear pore

Biological Process

• GO:0006913 nucleocytoplasmic transport
• GO:0006999 nuclear pore organization
• GO:0015031 protein transport
• GO:0046822 regulation of nucleocytoplasmic transport
• GO:0051028 mRNA transport

Cellular Component

• GO:0005634 nucleus
• GO:0005635 nuclear envelope
• GO:0005643 nuclear pore
• GO:0044611 nuclear pore inner ring

External links

• PDB: RCSB:8tj5, PDBe:8tj5, PDBj:8tj5
• PDBsum: 8tj5
• PubMed: 37738963
• UniProt: P47054|NU192_YEAST Nucleoporin NUP192 (Gene Name=NUP192)