Structure of PDB 8ifl Chain O

Receptor sequence

>8iflO (length=427) Species: 1393122 (Thermoflavifilum thermophilum) [Search protein sequence]

MKELIYIEEPSILFAHGQKCTDPRDGLALFGPLNQIYGIKSGVVGTQKGL
QIFKSYLDKIQKPIYNHNNITRPMFPGFEAVFGCKWESQNIVFKEITKRT
YDLVTLFNDKIITANKNDEERVDVWFVIVPEYDAQFHDQLKARLLEHTIP
TQILRESTLAWRDFKNTFGAPIRDFSKIEGHLAWTISTAAYYKAGGKPWK
LPGVCYLGLVYKKIQNACCAAQMFLDNGDGTVFKGEVGPWYNPEKGEYHL
KPKEAKALLTQALESYKEQNKSYPKEVFIHARTRFNDEEWNAFNEVTPKN
TNLVGVTITKSKPLKLYKTEGAFPIMRGNAYIVDEKKAFLWTLGFVPKLQ
STLSMEVPNPIFIEINKGEAEIQQVLKDILALTKLNYNACIYADGEPVTL
RFANKIGEILTASTEIKTPPLAFKYYI

3D structure

PDB

8ifl Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system.

Chain

Resolution

3.11 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	O	D203 A204 F206 H207 K211 I223 L224 R225 T228 F245 I248 L252 T255 G326 E327 L423 S434 E436 N439 N468 A469 I471 D474 G475 E476 R481 I507	D133 A134 F136 H137 K141 I153 L154 R155 T158 F175 I178 L182 T185 G246 E247 L343 S354 E356 N359 N388 A389 I391 D394 G395 E396 R401 I427
BS02	dna	O	H67 N68 R72 D244 I248 K286 K287 Y328 R362 T363 R364 A402 F403 S431 T432 M435	H67 N68 R72 D174 I178 K212 K213 Y248 R282 T283 R284 A322 F323 S351 T352 M355

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding

View graph for
Molecular Function

External links

PDB	RCSB:8ifl, PDBe:8ifl, PDBj:8ifl
PDBsum	8ifl
PubMed	37932528
UniProt	A0A1I7NFD7

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