Structure of PDB 8i0w Chain O

Receptor sequence
>8i0wO (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
DFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPGVRMRFKKT
EVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYYT
QNMEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFW
VKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRAS
TMPDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRTITVVQRQQCA
FIQFATRQAAEVAAEKSFNKLIVNGRRLNVKWG
3D structure
PDB8i0w Molecular basis for the activation of human spliceosome
ChainO
Resolution3.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0036002 pre-mRNA binding
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0033120 positive regulation of RNA splicing
GO:0042307 positive regulation of protein import into nucleus
GO:0045292 mRNA cis splicing, via spliceosome
GO:0046827 positive regulation of protein export from nucleus
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8i0w, PDBe:8i0w, PDBj:8i0w
PDBsum8i0w
PubMed39068178
UniProtQ9NW64|RBM22_HUMAN Pre-mRNA-splicing factor RBM22 (Gene Name=RBM22)

[Back to BioLiP]