Structure of PDB 8ea4 Chain O

Receptor sequence

>8ea4O (length=601) Species: 34078 (Scytonema hofmannii) [Search protein sequence]

SQITIQARLISFESNRQQLWKLMADLNTPLINELLCQLGQHPDFEKWQQK
GKLPSTVVSQLCQPLKTDPRFAGQPSRLYMSAIHIVDYIYKSWLAIQKRL
QQQLDGKTRWLEMLNSDAELVELSGDTLEAIRVKAAEILAIAMSLSKTLF
DAYQETEDIKSRSAISYLLKNGCKLTDKEEDSEKFAKRRRQVEIQIQRLT
EKLISRMPKGRDLTNAKWLETLLTATTTVAEDNAQAKRWQDILLTRSSSL
PFPLVFETNEDMVWSKNQKGRLCVHFNGLSDLIFEVYCGNRQLHWFQRFL
EDQQTKRKSKNQHSSGLFTLRNGHLVWLEGEGKGEPWNLHHLTLYCCVDN
RLWTEEGTEIVRQEKADEITKFITNMKSDTQQALIQRKQSTLTRINNSFE
RPSQPLYQGQSHILVGVSLGLEKPATVAVVDAIANKVLAYRSIKQLLGDN
YELLNRQRRQQQYLSHERHKAQKNFSPNQFGASELGQHIDRLLAKAIVAL
ARTYKAGSIVLPKLGDMREVVQSEIQAIAEQKFPGYIEGQQKYAKQYRVN
VHRWSYGRLIQSIQSKAAQTGIVIEEGKQPIRGSPHDKAKELALSAYNLR
L

3D structure

PDB

8ea4 Structures of the holo CRISPR RNA-guided transposon integration complex.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	O	Y89 K92 S93 I97 K266 D270 L273 T274 R275 E286 T287 S343 S344 G345 R350 N351 R421 S424 T425 R428 R502 Q513 G515 S517 R552 Y570 I571 E572 H586 G591 R592	Y88 K91 S92 I96 K237 D241 L244 T245 R246 E257 T258 S314 S315 G316 R321 N322 R387 S390 T391 R394 R468 Q479 G481 S483 R518 Y536 I537 E538 H552 G557 R558
BS02	dna	O	S77 S309 T414 L418 R421 F567	S76 S280 T380 L384 R387 F533
BS03	rna	O	Q3 I4 T5 Q7 I11 S12 R17 I90 W94 R227 K231 S234 R235 P237 R240 Q269 F281 R300 L301 Y316 C317 G318 N319 R320 Q321 L322 H323 K362 W382 P436 Y474 S476 K478 Q479 N489 R490 R493 Y497 H500 H503 K504 Q506 N508 F509 P511 E518 L519 H522 R525 K529 K579 R582 V583 H586 K600 Q603 H620	Q2 I3 T4 Q6 I10 S11 R16 I89 W93 R198 K202 S205 R206 P208 R211 Q240 F252 R271 L272 Y287 C288 G289 N290 R291 Q292 L293 H294 K333 W353 P402 Y440 S442 K444 Q445 N455 R456 R459 Y463 H466 H469 K470 Q472 N474 F475 P477 E484 L485 H488 R491 K495 K545 R548 V549 H552 K566 Q569 H586

External links

PDB	RCSB:8ea4, PDBe:8ea4, PDBj:8ea4
PDBsum	8ea4
PubMed	36442503
UniProt	A0A8M0FGU0

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