Structure of PDB 7wtx Chain O

Receptor sequence

>7wtxO (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]

LGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADR
DESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSAL
RALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL

3D structure

PDB

7wtx The nucleoplasmic phase of pre-40S formation prior to nuclear export.

Chain

Resolution

3.1 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	O	F37 N38 D39 F41 H43 G49 E51 T52 R55 T57 G59 D65 R66 E68 R98 P134 I135 P136 S137 D138 T140 R141 R142 K143 G144 R146 R147 R149 L151	F21 N22 D23 F25 H27 G33 E35 T36 R39 T41 G43 D49 R50 E52 R82 P118 I119 P120 S121 D122 T124 R125 R126 K127 G128 R130 R131 R133 L135

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0045182	translation regulator activity
GO:0048027	mRNA 5'-UTR binding

	Biological Process
GO:0000028	ribosomal small subunit assembly
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0006417	regulation of translation
GO:0030218	erythrocyte differentiation
GO:0030490	maturation of SSU-rRNA
GO:0042274	ribosomal small subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7wtx, PDBe:7wtx, PDBj:7wtx
PDBsum	7wtx
PubMed	36321656
UniProt	P62263\|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)