Structure of PDB 7pzy Chain O

Receptor sequence

>7pzyO (length=150) Species: 237561 (Candida albicans SC5314)

GRMHSSGKGISSSALPYSRNAPSWFKLSSDDVVEQIIKYARKGLTPSQIG
VILRDAHGVSQAKVVTGNKILRILKSNGLAPEIPEDLYYLIKKAVSVRKH
LEKNRKDKDSKFRLILIESRIHRLARYYRTVAVLPPNWKYESATASALVA

3D structure

• PDB: 7pzy E-site drug specificity of the human pathogen Candida albicans ribosome.
• Chain: O
• Resolution: 2.32 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	O	H123 K140	H122 K139
BS02	rna	O	G2 R3 M4 H5 G8 K9 G10 I11 S12 S14 A15 P17 R20 P47 S48 G51 V52 R55 S61 Q62 K64 K70 I71 L72 R73 K76 D87 Y90 K94 S97 V98 H101 N105 K107 D108 K109 D110 K112 F113 R114 I116 L117 S120 R121 R124 R127 Y128	G1 R2 M3 H4 G7 K8 G9 I10 S11 S13 A14 P16 R19 P46 S47 G50 V51 R54 S60 Q61 K63 K69 I70 L71 R72 K75 D86 Y89 K93 S96 V97 H100 N104 K106 D107 K108 D109 K111 F112 R113 I115 L116 S119 R120 R123 R126 Y127

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0070181 small ribosomal subunit rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0030446 hyphal cell wall
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7pzy, PDBe:7pzy, PDBj:7pzy
• PDBsum: 7pzy
• PubMed: 35613268
• UniProt: A0A1D8PPE0|RS13_CANAL Small ribosomal subunit protein uS15 (Gene Name=RPS13)