Structure of PDB 7mgz Chain O

Receptor sequence

>7mgzO (length=542) Species: 9606 (Homo sapiens) [Search protein sequence]

MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTF
SPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINK
ERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGT
VGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNS
VRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSI
YRVPLLLEEQGVVDYFLRRLDLPKMLMKWKEMADRYDRLLETCSIALVGK
YTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHE
AWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAV
VEFSRNVLGWQDANSTEFDPTTSHPVVVDMPEHNMRLGKRRTLFQTKNSV
MRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVE
LEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSHYL

3D structure

PDB

7mgz Structural basis for isoform-specific inhibition of human CTPS1.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.3.4.2: CTP synthase (glutamine hydrolyzing).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	UTP	O	S12 K38 D40 P41 Y42 G148 G149	S12 K38 D40 P41 Y42 G148 G149
BS02	GLN	O	G371 G372 F373 C399 Q403 E423 H480 R481 F482	G365 G366 F367 C393 Q397 E417 H467 R468 F469
BS03	MG	O	D70 E146	D70 E146
BS04	ANP	O	G13 I14 G15 K16 G17 I18 R217	G13 I14 G15 K16 G17 I18 R217
BS05	UTP	O	K193 T194 K195 Q198 K229	K193 T194 K195 Q198 K229

Gene Ontology

	Molecular Function
GO:0003883	CTP synthase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0042802	identical protein binding

	Biological Process
GO:0002376	immune system process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006541	glutamine metabolic process
GO:0009410	response to xenobiotic stimulus
GO:0019637	organophosphate metabolic process
GO:0019856	pyrimidine nucleobase biosynthetic process
GO:0042098	T cell proliferation
GO:0042100	B cell proliferation
GO:0044210	'de novo' CTP biosynthetic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0097268	cytoophidium

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7mgz, PDBe:7mgz, PDBj:7mgz
PDBsum	7mgz
PubMed	34583994
UniProt	P17812\|PYRG1_HUMAN CTP synthase 1 (Gene Name=CTPS1)

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