Structure of PDB 7c5q Chain O

Receptor sequence

>7c5qO (length=334) Species: 469008 (Escherichia coli BL21(DE3))

SMSKVGINGFGRIGRLVLRRLLEVKSNIDVVAINDLTSPKILAYLLKHDS
NYGPFPWSVDFTEDSLIVDGKSIAVYAEKEAKNIPWKAKGAEIIVECTGF
YTSAEKSQAHLDAGAKKVLISAPAGEMKTIVYNVNDDTLDGNDTIVSVAS
CTTNCLAPMAKALHDSFGIEVGTMTTIAAYTGTQSLVDGPRGKDLRASRA
AAENIIPHTTGAAKAIGLVIPELSGKLKGHAQRVPVKTGSVTELVSILGK
KVTAEEVNNALKQATTNNESFGYTDEEIVSSDIIGSHFGSVFDATQTEIT
AVGDLQLVKTVAWYDNEYGFVTQLIRTLEKFAKL

3D structure

• PDB: 7c5q Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.
• Chain: O
• Resolution: 2.13 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	O	G8 G10 R11 I12 D34 L35 K78 C96 T97 G98 F99 S120 C150 N315 F319	G9 G11 R12 I13 D35 L36 K79 C97 T98 G99 F100 S121 C151 N316 F320
BS02	G3H	O	T180 T182 H207 R232	T181 T183 H208 R233
BS03	PO4	O	H163 G167 I168 K225	H164 G168 I169 K226

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0042802 identical protein binding
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7c5q, PDBe:7c5q, PDBj:7c5q
• PDBsum: 7c5q
• PubMed: 34827563
• UniProt: A0A140NCK4