Structure of PDB 7c5p Chain O

Receptor sequence

>7c5pO (length=334) Species: 469008 (Escherichia coli BL21(DE3))

SMSKVGINGFGRIGRLVLRRLLEVKSNIDVVAINDLTSPKILAYLLKHDS
NYGPFPWSVDFTEDSLIVDGKSIAVYAEKEAKNIPWKAKGAEIIVECTGF
YTSAEKSQAHLDAGAKKVLISAPAGEMKTIVYNVNDDTLDGNDTIVSVAS
CTTNCLAPMAKALHDSFGIEVGTMTTIHAYTGTQSLVDGPRGKDLRASRA
AAENIIPHTTGAAKAIGLVIPELSGKLKGHAQRVPVKTGSVTELVSILGK
KVTAEEVNNALKQATTNNESFGYTDEEIVSSDIIGSHFGSVFDATQTEIT
AVGDLQLVKTVAWYDNEYGFVTQLIRTLEKFAKL

3D structure

• PDB: 7c5p Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.
• Chain: O
• Resolution: 2.35 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	O	G10 R11 I12 D34 L35 K78 C96 T97 F99 S120 C150 N315 F319	G11 R12 I13 D35 L36 K79 C97 T98 F100 S121 C151 N316 F320
BS02	G3H	O	T180 G181 T182	T181 G182 T183
BS03	PO4	O	H163 G167 I168 K225	H164 G168 I169 K226

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0042802 identical protein binding
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7c5p, PDBe:7c5p, PDBj:7c5p
• PDBsum: 7c5p
• PubMed: 34827563
• UniProt: A0A140NCK4