Structure of PDB 7as4 Chain O

Receptor sequence
>7as4O (length=420) Species: 9606 (Homo sapiens) [Search protein sequence]
REIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATDRKDVFFYQA
DDEHYIPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLGNNWASGFSQGE
KIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYP
KKLVQTYSVFPNQDEDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIA
TDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTP
RLHFLMTGYTPLTTDKTTVLDVMRRLLQPKNVMVSTNHCYIAILNIIQGE
VDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLM
MANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDEMDTSREI
VQQLIDEYHAATRPDYISWG
3D structure
PDB7as4 Assembly of the asymmetric human gamma-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase.
ChainO
Resolution4.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP O Q12 C13 Q16 G143 T145 Q175 N207 F225 N229 Q10 C11 Q14 G131 T133 Q163 N193 F211 N215
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042802 identical protein binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
GO:0007020 microtubule nucleation
GO:0007052 mitotic spindle organization
GO:0031122 cytoplasmic microtubule organization
Cellular Component
GO:0000242 pericentriolar material
GO:0000794 condensed nuclear chromosome
GO:0000930 gamma-tubulin complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005827 polar microtubule
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0005881 cytoplasmic microtubule
GO:0005929 cilium
GO:0015630 microtubule cytoskeleton
GO:0031252 cell leading edge
GO:0036064 ciliary basal body
GO:0043005 neuron projection
GO:0045177 apical part of cell
GO:0055037 recycling endosome
GO:0097730 non-motile cilium
GO:1990498 mitotic spindle microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7as4, PDBe:7as4, PDBj:7as4
PDBsum7as4
PubMed33355144
UniProtP23258|TBG1_HUMAN Tubulin gamma-1 chain (Gene Name=TUBG1)

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