Structure of PDB 6zxf Chain O

Receptor sequence

>6zxfO (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]

NVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAAM
LAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMK
IGRIEDVTPIPSDSTRRKGGRRGRRL

3D structure

PDB

6zxf Structural basis for the final steps of human 40S ribosome maturation.

Chain

Resolution

3.7 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	O	N38 D39 H43 G49 K50 T52 R55 T57 G59 M60 D65 R66 E68 R98 I135 P136 S137 D138 T140 R141 K143 R146 R147 R149 R150	N13 D14 H18 G24 K25 T27 R30 T32 G34 M35 D40 R41 E43 R73 I110 P111 S112 D113 T115 R116 K118 R121 R122 R124 R125

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0045182	translation regulator activity
GO:0048027	mRNA 5'-UTR binding

	Biological Process
GO:0000028	ribosomal small subunit assembly
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0006417	regulation of translation
GO:0030218	erythrocyte differentiation
GO:0030490	maturation of SSU-rRNA
GO:0042274	ribosomal small subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6zxf, PDBe:6zxf, PDBj:6zxf
PDBsum	6zxf
PubMed	33208940
UniProt	P62263\|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)