Structure of PDB 6xz7 Chain O

Receptor sequence

>6xz7O (length=117) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVA
ASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYH
GRVQALADAAREAGLQF

3D structure

PDB

6xz7 Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to theE. coli70S ribosome.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	O	R9 R10 T12 R13 R16 R94 Q98 Y99 F117	R9 R10 T12 R13 R16 R94 Q98 Y99 F117
BS02	rna	O	K3 R15 R25 H29 R30 T31 P32 R33 H34 Y36 Q38 G44 S45 E46 V47 V54 E55 K56 K63 Y64 N67 K68 H100 G101 R102	K3 R15 R25 H29 R30 T31 P32 R33 H34 Y36 Q38 G44 S45 E46 V47 V54 E55 K56 K63 Y64 N67 K68 H100 G101 R102

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6xz7, PDBe:6xz7, PDBj:6xz7
PDBsum	6xz7
PubMed	32144191
UniProt	P0C018\|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)

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