Structure of PDB 6txc Chain O

Receptor sequence

>6txcO (length=465) Species: 9606 (Homo sapiens) [Search protein sequence]

MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNR
AIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNF
TKPQDGDVIAPLITP

3D structure

PDB

6txc Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

2.84 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DTP	O	V156 F157 R372 H376 K377	V42 F43 R254 H258 K259
BS02	DTP	O	R333 R352 K354 N358 K523	R215 R234 K236 N240 K395
BS03	FE	O	H167 H206 D207 D311	H53 H92 D93 D193
BS04	0KX	O	Q149 L150 R164 D207 H215 H233 D311 K312 Y315 D319 R366 Y374	Q35 L36 R50 D93 H101 H119 D193 K194 Y197 D201 R248 Y256
BS05	GTP	O	K116 V117 I118 D137 R145 F165	K2 V3 I4 D23 R31 F51
BS06	GTP	O	Y155 V156 V378 R451	Y41 V42 V260 R333

External links

PDB	RCSB:6txc, PDBe:6txc, PDBj:6txc
PDBsum	6txc
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

[Back to BioLiP]