Structure of PDB 6iy2 Chain O

Receptor sequence

>6iy2O (length=580) Species: 559292 (Saccharomyces cerevisiae S288C)

LLDQTKDTRITHLLRQTNAFLDYYNVAHRIKEDIKKQPSILVGGTLKDYQ
IKGLQWMVSLFNNHLNGILADEMGLGKTIQTISLLTYLYEMKNIRGPYLV
IVPLSTLSNWSSEFAKWAPTLRTISFKGSPNERKAKQAKIRAGEFDVVLT
TFEYIIKERALLSKVKWVHMIIDEGHRMKNAQSKLSLTLNTHYHADYRLI
LTGTPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPFDKIELSEEETL
LVIRRLHKVLRPFLLRRLKKDVEKELPDKVEKVVKCKMSALQQIMYQQML
KYRRLGFNNQIMQLKKICNHPFVFEEVEDQINPTRETNDDIWRVAGKFEL
LDRILPKLKATGHRVLIFFQMTQIMDIMEDFLRYINIKYLRLDGHTKSDE
RSELLRLFNAPDSEYLCFILSTRAGGLGLNLQTADTVIIFDTDWNPHQDL
QAQDRAHRIGQKNEVRILRLITTNSVEEVILERAYKKLDIDGKVIQAGKF
DNKSTSEEQEALLRSLLDAEEERRKKRELKDSEINEILARNDEEMAVLTR
MDEDRSKKEEKSRLLEKKREESESAAVYNG

3D structure

• PDB: 6iy2 Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
• Chain: O
• Resolution: 3.47 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	O	L825 R854 E874 Y875 N1050 M1053 K1057 M1112 T1113 Q1114 S1162	L104 R133 E153 Y154 N309 M312 K316 M371 T372 Q373 S421
BS02	dna	O	R898 K900 S904 K905 L906 N929 I1052 W1185 N1186 R1224	R177 K179 S183 K184 L185 N208 I311 W444 N445 R483
BS03	ADP	O	T766 K768 Q771 M794 G795 L796 G797 K798 T799	T45 K47 Q50 M73 G74 L75 G76 K77 T78

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0042393 histone binding
• GO:0140658 ATP-dependent chromatin remodeler activity

External links

• PDB: RCSB:6iy2, PDBe:6iy2, PDBj:6iy2
• PDBsum: 6iy2
• PubMed: 30867599
• UniProt: P22082|SNF2_YEAST Transcription regulatory protein SNF2 (Gene Name=SNF2)