Structure of PDB 6i3m Chain O

Receptor sequence
>6i3mO (length=396) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
QATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKI
YKCQEEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSGAAVMDA
ALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEHQ
KSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISP
RLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRPGIVTIQ
CKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGA
KGHLPNIYTDIEINYFLLRRLLGVKKQAKVRKLEPNEVLMVNIGSTATGA
RVVAVKADMARLQLTSPACTEINEKIALSRRIEKHWRLIGWATIKK
3D structure
PDB6i3m The structural basis of translational control by eIF2 phosphorylation.
ChainO
Resolution3.93 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A110 K113 S114 T137 H197
Catalytic site (residue number reindexed from 1) A13 K16 S17 T40 H84
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide O Q248 Q263 I280 P282 S284 Y289 N290 D292 A293 Q135 Q150 I167 P169 S171 Y176 N177 D179 A180
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0031369 translation initiation factor binding
GO:1990856 methionyl-initiator methionine tRNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0045903 positive regulation of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0043614 multi-eIF complex

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Cellular Component
External links
PDB RCSB:6i3m, PDBe:6i3m, PDBj:6i3m
PDBsum6i3m
PubMed31086188
UniProtP32481|IF2G_YEAST Eukaryotic translation initiation factor 2 subunit gamma (Gene Name=GCD11)

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