Structure of PDB 6dlw Chain O

Receptor sequence
>6dlwO (length=460) Species: 9606 (Homo sapiens) [Search protein sequence]
SHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQC
VPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEP
RPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGN
TLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAA
FRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTF
VDDIKALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKR
KGVELKDIKRCLGYHLFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGT
RKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVK
MKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFK
FEGIACEISK
3D structure
PDB6dlw The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
ChainO
Resolution3.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA O W27 R42 W10 R25
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0001906 cell killing
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0044218 other organism cell membrane
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6dlw, PDBe:6dlw, PDBj:6dlw
PDBsum6dlw
PubMed30111885
UniProtP02748|CO9_HUMAN Complement component C9 (Gene Name=C9)

[Back to BioLiP]